Plasma Factor XIII Accelerates Bone Formation in the Treatment of Bone Defects
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چکیده
INTRODUCTION: Callus distraction is a well-accepted method for treating large bone defects. Unfortunately, the time for the maturation of a newly formed regenerate is long and can lead to complications. A method which would allow the acceleration of the maturation process would shorten the treatment time, reduce the costs and would be a great benefit for the patients. Plasma factor XIII has demonstrated an enhancing effect on the proliferation of osteoblasts [1] and fibroblast [2], and for the healing of diaphyseal fractures [3]. Therefore, the hypothesis should be tested whether plasma factor XIII can also accelerate bone formation after callus distraction.
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